Clinical Reports

1.Akhavan, O., et al., Hydrogen-rich water for green reduction of graphene oxide suspensions. International Journal of Hydrogen Energy, 2015. 40(16): p. 5553-5560.

2.Berjak, P., et al., Cathodic amelioration of the adverse effects of oxidative stress accompanying procedures necessary for cryopreservation of embryonic axes of recalcitrant-seeded species. Seed Science Research, 2011. 21(3): p. 187-203.

3.Hanaoka, K., Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions. Journal of Applied Electrochemistry, 2001. 31(12): p. 1307-1313.

4.Hanaoka, K., et al., The mechanism of the enhanced antioxidant effects against superoxide anion radicals of reduced water produced by electrolysis. Biophysical Chemistry, 2004. 107(1): p. 71-82.

5.Hiraoka, A., et al., In Vitro Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives. Journal of Health Science, 2010. 56(2): p. 167-174.

22.Cai, W.W., et al., Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast. Mol Cell Biochem, 2013. 373(1-2): p. 1-9.

23.Fujita, R., et al., Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle. Journal of Physiological Anthropology, 2011. 30(5): p. 195-201.

24.Guo, J.D., et al., Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol, 2013. 168(6): p. 1412-20.

25.Hanaoka, T., et al., Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Medical Gas Research, 2011. 1(1): p. 18.

26.Itoh, T., et al., Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochemical and Biophysical Research Communications, 2011. 411(1): p. 143-9.

54.Kashiwagi, T., et al., Electrochemically reduced water protects neural cells from oxidative damage. Oxid Med Cell Longev, 2014. 2014: p. 869121.

55.Kobayashi, H., et al., Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model. Journal of Neurotrauma, 2011. 28(5): p. A64-A64.

56.Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: alpha P-31-NMR study. Neuroscience Research, 2009. 65: p. S124-S124.

57.Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: A P-31-NMR and ESR study. Neuroscience Research, 2011. 71: p. E406-E406.

58.Li, J., et al., Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res, 2010. 1328: p. 152-161.

90.Akio Kagawa, K.K., Masayuki Mizumoto, Yutaka Tagawa, Yoichi Masiko, Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells. Materials Science Forum, 2012. 706: p. 520-525.

91.Asada, R., et al., Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Oncol Rep, 2010. 24(6): p. 1463-70.

92.Chen, Y., et al., On the antitumor properties of biomedical magnesium metal. Journal of Materials Chemistry B, 2015. 3(5): p. 849-858.93.Dole, M., F.R. Wilson, and W.P. Fife, Hyperbaric hydrogen therapy: a possible treatment for cancer. Science, 1975. 190(4210): p. 152-4.

94.Jun, Y., et al., Suppression of invasion of cancer cells and angiogenesis by electrolyzed reduced water. In Vitro Cellular & Developmental Biology-Animal, 2004. 40: p. 79A-79A.

95.Kinjo, T., et al., Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells. Cytotechnology, 2012. 64(3): p. 357-371.

114.Chen, L., et al., Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect. PLoS One, 2014. 9(6): p. e100774.

115.Feng, M., et al., Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. Int J Ophthalmol, 2012. 5(2): p. 151-7.

116.Huang, L., et al., Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. Ophthalmic Res, 2012. 47(3): p. 122-7.

117.Kashiwagi, T., et al., Suppression of glutamate-induced neural cell death by electrolyzed-reduced water, in Animal Cell Technology: Basic & Applied Aspects. 2004, Springer Netherlands. p. 105-109.

118.Kikkawa, Y.S., et al., Hydrogen protects auditory hair cells from free radicals. Neuroreport, 2009. 20(7): p. 689-94.

243.Drabek, T. and P.M. Kochanek, Improving outcomes from resuscitation: from hypertension and hemodilution to therapeutic hypothermia to H2. Circulation, 2014. 130(24): p. 2133-5.

244.Fujii, Y., et al., Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model. Artif Organs, 2013. 37(2): p. 136-41.

245.Hayashi, T., et al., Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. American Journal of Physiology – Heart and Circulatory Physiology, 2011. 301(3): p. H1062-9.

246.Hayashida, K., et al., H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc, 2012. 1(5): p. e003459.

247.Hayashida, K., et al., Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest, Independent of Targeted Temperature Management. Circulation, 2014.

261.Aoki, K., et al., Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2012. 2(1): p. 12.

262.Bittner, A.C., et al., Intra-Individual Ergonomics (I2E): Performance Effects of Ultra-Negative-Ion Water. Proceedings of the Human Factors and Ergonomics Society Annual Meeting SAGE Journals, 2007. 55(26): p. 1617-1621.

263.Drid, P., et al., Hydrogen-Rich Water in Judo Training. . Psycho-Physiological, Spiritual and Ethical Aspects), 2013: p. 129.

264.Fujiyama, Y. and T. Kitahora, Alkaline electrolytic water (alkali ions water) for drinking water in medicine. Mizu no Tokusei to Atarashii Riyo Gijutsu, Enu-Ti-Esu, Tokyo, 2004: p. 348-457.

265.Hiraoka, A., et al., Effects of drinking a water product with anti-oxidant activities in vitro on the blood levels of biomarker substances for the oxidative stress. Journal of Health Science, 2006. 52(6): p. 817-820.

178.Ball, J., Recently published papers: More about EGDT, experimental therapies and some inconvenient truths. Critical Care, 2007. 11(5).

179.Cavallo, T., An essay on the medicinal properties of factitious airs: with an appendix on the nature of blood. 1798: Printed for the author, and sold by C. Dilly [and 2 others].

180.Chang, W.J. and L.H. Toledo-Pereyra, The potential benefits of hydrogen-rich saline in ischemia and reperfusion injury. Journal of Surgical Research, 2013. 180(2): p. 248-9.

181.Chen, X., X. Sun, and S. Ohta, Future Directions in Hydrogen Studies. Hydrogen Molecular Biology and Medicine. 2015: Springer Netherlands.

182.Chen, J., et al., Hydrogen therapy may be a promising, safe and effective treatment for diabetic erectile dysfunction: a hypothesis. Alternative Medicine Studies, 2011. 1(1): p. 11.

155.Carter, E.A., et al., Use of hydrogen gas (H2) analysis to assess intestinal absorption. Studies in normal rats and in rats infected with the nematode, Nippostrongylus brasiliensis. Gastroenterology, 1981. 81(6): p. 1091-7.

156.Chen, X., et al., Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen. Medical Gas Research, 2012. 2: p. 3.

157.Chen, X., et al., Lactulose Mediates Suppression of Dextran Sodium Sulfate-Induced Colon Inflammation by Increasing Hydrogen Production. Dig Dis Sci, 2013.

158.Chen, X., et al., Lactulose: an indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production. Medical Hypotheses, 2011. 76(3): p. 325-7.

159.Christl, S.U., et al., Production, metabolism, and excretion of hydrogen in the large intestine. Gastroenterology, 1992. 102(4 Pt 1): p. 1269-77.

132.Aoki, K., et al., Is hydrogen gas in water present as bubbles or hydrated form? Journal of Electroanalytical Chemistry, 2012. 668: p. 83-89.133.Black, J.H., Chemistry and cosmology. Faraday Discussions, 2006.

133: p. 27-32; discussion 83-102, 449-52.

134.Buxton, G.V., et al., Critical view of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (•OH/•OH–) in aqueous solution. J Phys Chem Ref Data, 1988. 17: p. 513-886.

135.Choi, W.K., Investigations of Quantitative Reducibility Determination and Reducibility Variations of Neutral Hydrogen-Dissolved Water by Electrochemical Analysis. Int. J. Electrochem. Sci, 2014. 9: p. 7266-7276.

136.Donald, W.A., et al., Directly relating gas-phase cluster measurements to solution-phase hydrolysis, the absolute standard hydrogen electrode potential, and the absolute proton solvation energy. Chemistry, 2009. 15(24): p. 5926-34.

298.Cai, J., et al., Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett, 2008. 441(2): p. 167-172.

299.Cai, J.M., et al., Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res, 2009. 1256: p. 129-137.

300.Chen, H., et al., The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. Journal of Surgical Research, 2011. 167(2): p. 316-22.

301.Fukuda, K., et al., Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun, 2007. 361(3): p. 670-674.

302.Ge, P., et al., Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurological Research, 2012. 34(2): p. 187-94.

338.Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation, 2012. 94(1): p. 14-21.

339.Cardinal, J.S., et al., Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International, 2010. 77(2): p. 101-9.

340.Homma, K., et al., Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. Nephron Exp Nephrol, 2015.

341.Gu, H., et al., Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res, 2014. 188(1): p. 243-9.

342.Katakura, M., et al., Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Medical Gas Research, 2012. 2(1): p. 18.

353.Gharib, B., et al., Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III, 2001. 324(8): p. 719-724.

354.Itoh, T., et al., Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun, 2009. 389(4): p. 651-6.

355.Kajiya, M., et al., Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun, 2009. 386(2): p. 316-21.

356.Koyama, Y., et al., Effects of Oral Intake of Hydrogen Water on Liver Fibrogenesis in Mice. Hepatol Res, 2013.

357.Koyama, Y., et al., Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 2014. 44(6): p. 663-677.

375.Du, Z., et al., Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock. Journal of Surgical Research, 2014. In press.

376.Fang, Y., et al., Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. Journal of Burn Care and Research, 2011. 32(3): p. e82-91.

377.Haam, S., et al., The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac deathdagger. Eur J Cardiothorac Surg, 2015.

378.Huang, C.S., et al., Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical Care, 2010. 14(6): p. R234.

379.Huang, C.S., et al., Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochemical and Biophysical Research Communications, 2011. 408(2): p. 253-8.

402.Abe, M., et al., Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level, in Animal Cell Technology: Basic & Applied Aspects. S. Netherlands, Editor. 2010. p. 315-321.

403.Amitani, H., et al., Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One, 2013. 8(1).

404.Baek, D.-H., Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria. 2013.

405.Chao, Y.C. and M.T. Chiang, Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats. Taiwanese Journal of Agricultural Chemistry and Food Science, 2009. 47(2): p. 71-72.

406.Chen, C.H., et al., Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience, 2010. 169(1): p. 402-414.

449.Chen, Y., et al., H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015.

450.Chen, Q., et al., Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci, 2013. 40(6): p. 857-63.

451.Ge, Y., et al., Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLoS One, 2014. 9(5): p. e97436.

452.Guan, Z., et al., Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet, 2015.

453.Kawaguchi, M., et al., Molecular hydrogen attenuates neuropathic pain in mice. PLoS One, 2014. 9(6): p. e100352.

476.Jung, H.S., et al., Evaluate of Electrochemical Characteristics in Electrolyzed Reduced Water. Korean J. Microscopy, 2008. 38(4): p. 321-324.

477.Kayar, S.R., E.C. Parker, and A.L. Harbin, Metabolism and thermoregulation in guinea pigs in hyperbaric hydrogen: Effects of pressure. Journal of Thermal Biology, 1997. 22(1): p. 31-41.

478.Lee, K.J., et al., The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice. Biol Pharm Bull, 2009. 32(3): p. 456-62.

479.Merne, M.E., K.J. Syrjanen, and S.M. Syrjanen, Systemic and local effects of long-term exposure to alkaline drinking water in rats. Int J Exp Pathol, 2001. 82(4): p. 213-9.

480.Ni, X.X., et al., Protective effect of hydrogen-rich saline on decompression sickness in rats. Aviation Space and Environmental Medicine, 2011. 82(6): p. 604-9.

492.Anami, S., K. Saegusa, and M. Nishikata, Effect of glutamine or alkaline ionized water on late diarrhea induced by irinotecan hydrochloride in Gunn rats. Asian Journal of Pharmaceutical Sciences, 2009. 4(2): p. 96-105.

493.Buchholz, B.M., et al., Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant, 2008. 8(10): p. 2015-2024.

494.Buchholz, B.M., et al., Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation, 2011. 92(9): p. 985-92.

495.Chen, H.G., et al., Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg, 2013. 11(10): p. 1060-6.

496.He, J., et al., Protective effects of hydrogen-rich saline on ulcerative colitis rat model. Journal of Surgical Research, 2013(0).

517.Chuai, Y., et al., Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochemical Journal, 2012. 442(1): p. 49-56.

518.Chuai, Y., et al., Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit, 2012. 18(3): p. BR89-94.

519.Guo, S.X., et al., Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One, 2015. 10(4): p. e0124897.

520.Ignacio, R.M., et al., The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med, 2013. 2013: p. 538673.

521.Ignacio, R.M., et al., The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Molecular & Cellular Toxicology, 2013. 9(1): p. 15-21.

538.Chen, C.W., et al., Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats. Neurochemical Research, 2010. 35(7): p. 1111-1118.

539.Chen, H., et al., Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun, 2010. 393(2): p. 308-313.

540.Hong, Y., S. Chen, and J.M. Zhang, [Research advances on hydrogen therapy in nervous system diseases]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(6): p. 638-43.

541.Ren, J., et al., Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg, 2012. 72(6): p. 1555-61.

542.Ren, J.D., et al., Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm, 2014. 2014: p. 930894.